Two sample MR report
HLA-DQA2_Conventional Dendritic Cell against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.2528950 | 1.5476050 | 0.8968810 |
| Weighted median | 3 | 0.1638141 | 0.0695586 | 0.0185202 |
| Inverse variance weighted | 3 | 0.1627887 | 0.0560947 | 0.0037075 |
| Simple mode | 3 | 0.1646562 | 0.0798552 | 0.1753302 |
| Weighted mode | 3 | 0.1649805 | 0.0834916 | 0.1868072 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0024782 | 1 | 0.9602964 |
| Inverse variance weighted | 0.0058726 | 2 | 0.9970680 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0310862 | 0.5335652 | 0.9629516 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.25e-05 | 0 | TRUE | 0.5903087 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
